Doxorubicin-Induced Cardiotoxicity: Mechanisms and Management

Unfortunately, anticancer medications are extremely harmful to normal cells. Doxorubicin (DOX) is a highly cardiotoxic medication that can result in cardiomyopathy. The most significant mechanism for DOX-induced cardiotoxicity oxidative stress, while other pathways have also been put forth. This review aims highlight the mechanisms of and updated managements. Trustworthy sites such as Google Scholar, PubMed, Research Gate were used find articles. Many titles searching, "doxorubicin cardiotoxicity," "cardioprotection," "cardio-protective effects phytochemicals." Preprints, articles, research with meta-analyses disregarded. Three pathways, including mitochondrial damage, calcium excess, responsible cardiotoxicity. Cardiotoxicity may be partially caused by cell death, activation ubiquitin-ligase-proteasome system, changes its gene expression brought on DOX. In instance DOX cardiotoxicity, nutraceuticals antioxidants iron chelating properties found cardio-protective benefits. conclusion, doxorubicin-treated cancer patients linked making cardioprotection important these patients. All included this review's discussion might provide light fresh approaches treatment and/or prevention